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Restless legs syndrome

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An urge to move that comes in the evening and steals sleep — often an iron deficiency lies behind it.

Also known as: restless legs syndrome · RLS

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This compilation is for information and replaces neither medical diagnosis nor treatment. If you have symptoms, see a doctor.

A hard-to-describe pulling, tingling or restlessness deep in the legs, together with an almost irresistible urge to move them. Four things belong together and make the diagnosis, which is reached by listening alone: the urge comes at rest, it gets better with movement, it is strongest in the evening and at night, and nothing else explains it. That very pattern separates it from cramps, from circulation problems and from nerve damage. The consequence is nearly always broken sleep, and the daytime tiredness is then experienced as a problem of its own, with no connection made to the legs. The most important correctable reason is the iron store: the brain needs iron to make dopamine, and a different yardstick applies here — a ferritin that looks unremarkable on the lab report can be too low for restless legs. So ferritin belongs measured and, when low, topped up before anything else is considered. Further reasons are pregnancy, weak kidneys and some medicines, in particular certain anti-sickness drugs and part of the antidepressants.

Levers & pathways

studiedHeme iron (meat/fish)

Iron from animal sources is best absorbed — red meat, liver, fish.

studiedVitamin C with plant iron

Vitamin C with the meal markedly boosts absorption of plant iron.

studiedIron supplement (if deficient)

Effective when deficient; every-other-day dosing is often better absorbed and tolerated than daily.

studiedMeasure ferritin — with a different yardstick

A higher lower limit applies here. A value that looks unremarkable on the report can be too low for restless legs — ask about this explicitly.

studiedGo through the medicine list

Some anti-sickness drugs and part of the antidepressants clearly worsen it. That belongs discussed, not stopped on your own.

studiedMove in the evening rather than sit long

A walk, stretching, a warm or cold bath — what helps varies. Very hard exercise late in the evening makes it worse for some.

associatedCheck caffeine and alcohol in the evening

Both increase the restlessness in some people. A two-week trial shows whether you are one of them.

studiedCareful with ever-rising doses

With some medicines for restless legs the condition can worsen in the long run under rising doses. Anyone needing more should report it rather than increase it.

studiedWhat the medicine does — and what it does not

Dopamine agonists help immediately. After months to years they can intensify the symptoms and shift them earlier in the day — this is called augmentation. So the iron store is filled first: here the target is a ferritin above 100, not the usual lower reference limit.

studiedNumbers and timeframes

Five to ten in a hundred adults are affected, women more often. It often begins before the age of forty and slowly grows stronger over the years. In pregnancy it is common and usually disappears again afterwards.

studiedMove rather than keep still

Get up, a few steps, stretch the calves, shower cold or warm. The urge eases with movement — that is both the hallmark and the lever.

Possible complaints

studiedThe urge comes as soon as you settle

At the cinema, on the train, in bed. It is not the time of day alone but sitting still that brings it on.

studiedStanding up helps at once

That is the most reliable hallmark. As soon as rest returns, the urge returns.

studiedStronger in the evening than the morning

A rhythm of its own, independent of how long you have been sitting. If it is missing, the diagnosis often does not fit.

studiedBroken sleep and daytime tiredness

Often what brings people in — the legs are not mentioned at all. Which is exactly why asking about them pays.

studiedNot the same as a calf cramp

A cramp is a hard, visibly shortened muscle and it hurts. The urge in restless legs is unpleasant, but it is not pain in the muscle.

studiedMore common in pregnancy

Above all in the last third, and usually over after the birth. Iron needs are then especially high.

Blood values

studiedFerritin

Low (even normal-range) often worsens RLS.

studiedTransferrin saturation

Complements ferritin in the iron work-up. In restless legs a rather high target ferritin is aimed for, because brain iron deficiency worsens symptoms — even with a “normal” blood count.

Nutrients

studiedIron

Refilling iron often clearly helps.

traditionalMagnesium

Widely used; there are few studies on it.

Supplements

studiedIron

Only if ferritin is low, medically guided.

infoMagnesium (glycinate/citrate)

Effective when deficient; effects on sleep and stress plausible but moderate. Too much causes loose stool.

Hormones

studiedDopamine

The messenger this is about — and it follows a daily rhythm with a low point in the evening. That is exactly why the restlessness in the legs begins when one comes to rest.

studiedIron-dependent dopamine production

To make this messenger the brain needs iron. That is why the ferritin is the most important blood value here of all — even with a completely normal blood count.

associatedOestradiol

In pregnancy, especially in the last third, the complaints often appear and usually disappear again after the birth.

Messengers

studiedDopamine

Dopaminergic dysfunction; L-DOPA and agonists help.

Food

studiedIron — here first

In restless legs a ferritin below 75 is considered worth treating — a markedly higher threshold than elsewhere. After correction symptoms clearly improve in some, often only after 8–12 weeks.

associatedCaffeine, alcohol and nicotine in the evening

All three increase the restlessness in the legs for many. Two weeks without show whether it applies personally.

Alternative approaches — what people use

studiedIron

A low ferritin is the most common treatable cause — the target here is higher than elsewhere.

studiedMovement & exercise

Regular, moderate movement relieves; intense exertion in the evening worsens it.

studiedMagnesium

Very commonly taken; controlled studies are rare.