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Liver cirrhosis

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The liver has so much reserve that nothing shows for a long time — and the two checks that decide the course are ultrasound and endoscopy.

Also known as: liver cirrhosis · end-stage liver scarring

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This compilation is for information and replaces neither medical diagnosis nor treatment. If you have symptoms, see a doctor.

Over years the liver replaces lost tissue with scar. The treacherous part is its own generosity: it has so much reserve that nothing shows for a long time — and when something does show, it is things nobody connects with the liver. Tiredness put down to age. Itching without a rash. Calf cramps. A belly that grows fuller while the arms grow thinner. Red palms and small spider-like vessels on chest and shoulders. The commonest causes are alcohol, fatty liver with overweight and diabetes, chronic viral hepatitis, and more rarely autoimmune, inherited and drug-related forms. The decisive distinction is between two phases: as long as the liver still manages its tasks, one can live well with cirrhosis for a very long time and the course can be influenced. If it tips, fluid in the belly, jaundice, confusion or bleeding from varices in the gullet follow — and then every week counts. Two examinations therefore shape everyday life: the regular ultrasound check and the endoscopy that looks for those varices before they announce themselves.

Levers & pathways

associatedThe cause that can be treated

Iron overload is one of the few causes of liver scarring that can be halted by simple means. It belongs excluded once in any unexplained liver disease — transferrin saturation and ferritin.

studiedLeave alcohol out entirely

Regardless of whether it was the cause. It is the one measure that changes the course measurably at every stage — even late on.

studiedAn ultrasound every six months

Early detection of liver cancer runs through this appointment. It is unspectacular and the reason some courses end well.

studiedLook once for varices in the gullet

An endoscopy looks for them before they bleed. If any are found, there are drugs and procedures that prevent exactly that.

studiedEat protein, do not skimp

The old advice to avoid protein no longer holds. Muscle loss worsens the outlook, and portions spread across the day with a late evening snack are today’s advice.

studiedHave painkillers and supplements checked

Anti-inflammatory painkillers are especially delicate here, and some herbal products too. Paracetamol at a reduced dose is usually the better choice — the doctor decides.

studiedDiscuss infections early

A scarred liver makes infections more likely, and an infection can tip a stable situation. Fever therefore belongs assessed earlier than otherwise.

studiedA scarred liver hilum with no alcohol and no virus

The eggs scar the tissue around the portal vein while the liver cells stay healthy for a long time. With origin in an endemic area this belongs on the list.

studiedA liver overgrown from outside

The fox tapeworm grows by infiltration over years, dams the bile ducts and scars the tissue. It is often taken for a tumour; a blood test tells the two apart.

studiedWhat the medicine does — and what it does not

The medicines treat the consequences: diuretics the fluid in the belly, lactulose the clouding of the mind, beta blockers the pressure in the oesophageal varices. The scar tissue itself stays. What changes the course is removing the cause — with alcohol and fatty liver the liver does reverse at early stages.

infoNumbers and timeframes

The liver has a large reserve — symptoms often appear only when a large part is scarred, and with alcohol and fatty liver that usually takes ten to twenty years. Compensated cirrhosis without complications has a life expectancy of over twelve years, decompensated considerably less — the transition is the decisive point. With known cirrhosis, an ultrasound for cancer screening is done every six months and a scope looks once for varices in the oesophagus.

Possible complaints

associatedNothing at all for a long time

The reserve is so large that many are only noticed when a blood count or ultrasound is done for another reason.

associatedItching without a rash

All over, worse at night, with nothing to see on the skin. It is regularly taken for dry skin.

associatedThe belly fills, the arms thin

Fluid collects in the belly while muscle is lost. That combination says more than the weight on the scales.

associatedSigns on skin and hands

Reddened palms, small spider-like vessels on chest and shoulders, brittle nails, bruises from the slightest knock.

associatedWhen it tips

Yellow eyes, a growing belly, confusion or a reversed day-night rhythm, black stools or vomiting blood — any one of these means hospital at once.

studiedFull after a few bites

If water collects in the abdomen, less room is left for the stomach. That explains a growing belly and a shrinking appetite at once.

Blood values

studiedAlbumin

One of the proteins only the liver makes. If it falls, that says more about the liver’s performance than any liver enzyme — and it explains the fluid in the tissues.

studiedINR (clotting)

The clotting factors also come from the liver. A rising value without blood thinners is a measure of performance, not a clotting problem.

studiedBilirubin

When it rises, the eyes yellow first. Together with albumin and INR it gives the picture by which severity is graded.

studiedBlood count

Falling platelets are often the very earliest sign — they show the back-pressure before the liver, long before anything is felt.

Nutrients

studiedVitamin B1 (thiamine)

The store lasts only a few weeks and empties quickly with alcohol and poor food. A lack hits nerves and brain first — which is why it is corrected here early and without hesitating.

associatedFolate

The liver is the store, and alcohol disturbs both the uptake and the storing. A lack shows in the blood count as red cells that are too large.

associatedZinc

With advanced liver disease a lack is common and contributes to loss of taste, poor wound healing and states of confusion.

studiedProtein

The old rule of restricting protein in liver disease no longer holds. Too little of it breaks muscle down, and muscle is an important part of the reserve in this illness.

Supplements

mixedBCAA

Branched-chain amino acids are one of the few supplements with data in cirrhosis: they improve nutritional state and muscle mass. Studied over months, often as an evening portion.

mixedZinc

In cirrhosis zinc is often low, and a deficiency worsens the confusion in hepatic encephalopathy. Measure before supplementing.

infoFolic acid / folate

In pregnancy clearly established against neural-tube defects, otherwise mainly with deficiency. Can mask a B12 deficiency — watch both.

Hormones

studiedEstradiol

The liver breaks hormones down. When it can no longer manage that, the balance shifts: in men this leads to breast enlargement, loss of body hair and smaller testicles — visible signs of an internal reckoning.

studiedAldosterone

With cirrhosis this hormone is no longer properly broken down and at the same time produced more. It holds sodium and water back — that is the core of the fluid in the belly, and why of all things an aldosterone blocker works here.

associatedIGF-1

Almost all of the body’s IGF-1 comes from the liver. With advanced cirrhosis it falls — one of the reasons for the muscle wasting that shapes the course.

Food

associatedSalt-/protein-aware, no alcohol

Individualised medically.

Alternative approaches — what people use

mixedMilk thistle

Studied in cirrhosis without clear benefit on survival or complications. Important: in advanced liver disease herbal preparations are broken down more slowly — this belongs discussed with the treating team.

studiedMovement & exercise

Muscle loss in cirrhosis worsens the outlook. Strength training counters it; in studies it improved muscle mass and stamina over 12 weeks.

Wild herbs — what is traditionally used

traditionalDandelion

The bitter compounds in the root stimulate bile flow — that is the traditional use. With advanced liver disease it changes nothing about the course, and there the amount of fluid and salt matters more.

infoWormwood

Here as a warning: wormwood contains thujone and is traditionally set in alcohol. Both are the wrong thing with a damaged liver.

Essential oils — use and limits

infoOregano

Here as a warning: essential oils are broken down in the liver, and the sharp phenolic oils such as oregano and thyme-thymol are borderline internally even with a healthy liver. With cirrhosis they do not belong in the mouth.

TCM — how it is seen there

traditionalAristolochic acid & unsafe herbs

Aristolochic acid in individual Chinese herbs has caused severe kidney and liver damage — the warning is in the TCM tool.

Frequencies — what is on file

traditionalLiver – organ frequency

Listed values: 214 Hz

traditionalLiver burden

Listed values: 146 · 174 · 285 · 417 · 528 · 3030 · 4150 Hz