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Macular degeneration (AMD)

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The spot of sharpest vision suffers — reading gets hard, orientation remains.

Also known as: age-related macular degeneration · AMD

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This compilation is for information and replaces neither medical diagnosis nor treatment. If you have symptoms, see a doctor.

Wear of the macula (the spot of sharpest vision) — distorted or missing central vision while the outer field remains. Main risks: age, smoking, genetics. In the wet form, injections into the eye can help. Certain nutrient combinations (lutein/zeaxanthin, zinc, vitamins C/E, omega-3) can slow progression (AREDS studies). In the dry form certain nutrient combinations (following the AREDS trials) can slow progression.

Levers & pathways

studiedThe Amsler grid once a week

A sheet with a grid pattern, each eye on its own, glasses on. Bent lines or a grey patch that is new belong at the eye doctor within days — with the wet form every week counts.

studiedSmoking is the strongest single factor

It doubles to triples the risk and speeds up the course. Stopping smoking works more strongly here than any supplement.

studiedThe wet form is treatable

Injections into the eye halt the course for many and often even improve sight. But they have to be repeated regularly — keeping the appointments is the actual treatment here.

studiedGreen vegetables, fish, sunglasses

Dark green leafy vegetables, fish once or twice a week and protection from strong light are among the measures one holds oneself. Certain supplements come into question with the advanced dry form — the eye doctor decides that.

studiedVisual aids and lighting change a lot

Strong magnifiers, screen readers, text-to-speech and above all very bright, glare-free light make reading possible again, even when the middle is missing. This advice often comes far too late.

studiedWhat the medicine does — and what it does not

In the wet form, injections into the eye block a growth factor and dry up the leaking vessels — they preserve sight and must be repeated regularly. In the dry form there is no such option; there, stopping smoking and the AREDS nutrients count. Sight already lost does not return in either case.

infoNumbers and timeframes

About one in eight people over sixty and nearly one in three over eighty are affected. The dry form makes up around nine in ten cases and advances slowly over years; the wet form can cause a marked loss within weeks — which is why sudden distorted vision is a reason to be seen within days. Injections into the eye are given monthly at first and later as needed; they hold the state, they do not restore it.

Possible complaints

studiedStraight lines go crooked

Door frames, tile joints, window bars, the lines of a newspaper ripple or have a kink. That is the most important early sign — and it is only noticed with one eye covered.

studiedA grey patch in the middle

While reading letters are missing in the middle of the word, faces look smeared while everything around stays clear. The vision at the edge is kept — one does not go blind in the room.

studiedMore light needed, slow adaptation

Suddenly the lamp has to be right beside the book, and after going from bright to dark it takes long before anything can be seen again.

studiedA sudden worsening counts differently

If the distortion or the patch clearly increases within days, that speaks for the wet form. It can be treated, and the treatment is time-critical — here days count, not months.

Blood values

associatedOmega-3 index

No value detects the illness — examination of the retina and a scan do. Diet does demonstrably play a part, though, and this value reflects it.

associatedLDL cholesterol

The risk factors for the vessels overlap with those for the retina. Smoking is the strongest single factor among them.

associatedVitamin D (25-OH)

Belongs to general supply, not to the diagnosis. For the eyes themselves the regular checks and the Amsler grid count for more than any blood value.

Nutrients

studiedLutein

Key part of the AREDS formula; can slow progression.

studiedZinc

Part of the AREDS formula.

associatedVitamin C

Antioxidant in the AREDS formula.

associatedVitamin E

Antioxidant in the AREDS formula.

associatedOmega-3

Studied for the retina; mixed data.

traditionalBeta-carotene

In AREDS — AVOID in smokers (lung-cancer risk).

Supplements

studiedLutein

Core of AREDS2.

studiedZinc

Part of AREDS.

associatedOmega-3

For the retina.

Hormones

associatedEstradiol

Women are affected more often, partly because of the longer life expectancy. A protective effect of hormone treatment could not be shown in the large studies.

mixedMelatonin

In small studies melatonin was tested for its role in the eye; the results are not enough for a statement. What did work in large trials was a particular nutrient combination in advanced dry form — and stopping smoking.

Food

associatedLeafy greens (lutein)

Spinach, kale supply lutein/zeaxanthin.

Alternative approaches — what people use

studiedLutein & zeaxanthin

Lutein and zeaxanthin are the pigments of the macula itself; studied in large trials as a brake on the course.

studiedOmega-3 for the eyes

Tested in the same series of trials; there they showed no additional benefit.

traditionalBilberry & anthocyanins

Anthocyanins are traditionally used for the retina; the studies are small.