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Cluster headache

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Extremely severe one-sided attacks in series — treatable, but often mistaken for migraine.

Also known as: cluster headache · Horton’s headache

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This compilation is for information and replaces neither medical diagnosis nor treatment. If you have symptoms, see a doctor.

Extremely severe, strictly one-sided attacks around the eye and temple, in bouts (“clusters”) — often with a tearing eye, blocked nose and marked restlessness, frequently at night at the same time. Very treatable: acute relief usually from high-flow oxygen or a sumatriptan injection; prevention often with verapamil. Have it assessed by a neurologist.

Levers & pathways

studiedGet oxygen prescribed

High-flow oxygen through a non-rebreather mask ends many attacks within minutes. The device belongs at home, not in the emergency room — the attack is over before one gets there.

studiedInjection or nasal spray instead of a tablet

An attack peaks within minutes. A tablet takes too long; the form injected under the skin or sprayed into the nose works fast enough.

studiedKeep an attack calendar

Time of day, duration, side, what came before. The series often have a fixed time of day and a fixed season — that is the basis of any preventive treatment.

studiedAlcohol during the active phase

Within a series even one glass often triggers an attack within an hour. Between series that is usually not so — for many this difference is the clearest pointer to the diagnosis.

studiedPrevention needs a heart check

The most common preventive drug is increased slowly with an ECG alongside, because it can slow conduction in the heart. That is part of the plan, not of caution.

studiedDo not confuse it with migraine

With migraine one wants quiet and darkness; here one cannot keep still. The distinction decides the treatment — and it is often missed for years.

studiedWhat the medicine does — and what it does not

Oxygen through a mask and injected sumatriptan stop the attack within minutes. Verapamil prevents and needs weeks. Ordinary painkiller tablets come too late — the attack is over before they are in the blood.

infoNumbers and timeframes

The attack lasts fifteen minutes to three hours and comes in episodes: up to eight times a day over weeks to months, often at the same time of day and with a seasonal clustering. About one in a thousand people is affected, men more often. The pain sits on one side around the eye, with tearing, a running nose and a drooping lid on the same side. Oxygen at twelve to fifteen litres a minute through a mask ends the attack in about seven out of ten within fifteen minutes.

Possible complaints

studiedStrictly one-sided around the eye

A boring, burning pain behind or around one eye and at the temple that never changes side within a series. The intensity is often described as the worst someone knows.

studiedThe eye waters, the nose runs

On the same side: a watering and reddened eye, a drooping lid, a narrow pupil, a blocked or running nose, sweating on the face. These accompanying signs are decisive for the diagnosis.

studiedRestlessness instead of withdrawal

Unlike migraine it keeps no one still: pacing up and down, rocking, pressing the head against the wall. This difference alone often separates the two pictures.

studiedThe rhythm: at night, at the same time, in series

Attacks of fifteen minutes to three hours, one to eight times a day, often one to two hours after falling asleep, over weeks to months — and then months to years of quiet. Series cluster in spring and autumn.

Blood values

studiedESR (sedimentation rate)

Serves the distinction: one-sided pain around the eye in someone over fifty can also come from an inflammation of the arteries, which is treated at once.

associatedCRP

No value explains the pain itself. This one looks for the rare but important exception: an inflammation or infection behind the complaints.

associatedTSH (thyroid)

Belongs to the basic workup when the attacks are new or the pattern changes.

Nutrients

associatedVitamin D

Often low in patients; high-dose regimens being explored (limited evidence).

mixedMagnesium

Weak, inconsistent data.

Supplements

associatedMelatonin

At night — studied for prevention.

associatedVitamin D

Useful if deficient; high-dose protocols only under medical guidance.

infoMagnesium (glycinate/citrate)

Effective when deficient; effects on sleep and stress plausible but moderate. Too much causes loose stool.

Hormones

associatedMelatonin

Circadian control via the hypothalamus; levels often reduced — used preventively.

Food

studiedAvoid alcohol (during an active bout)

Alcohol reliably triggers attacks during active bouts.

Alternative approaches — what people use

studiedBreathing exercises

Oxygen through a mask ends the attack within 15 minutes for most and is the recognised acute treatment. Ordinary breathing exercises do not achieve this — the difference matters.

studiedSleep hygiene

Cluster attacks typically come at the same hour at night and follow the inner rhythm. Fixed sleep times and no alcohol during the cluster period are the two practical points.

Frequencies — what is on file

traditionalHeadaches of unknown cause

Listed values: 600 · 625 · 650 · 3000 Hz